Isotroin 20mg, a high-dose retinoid, commonly causes dry skin, lips, and eyes, as well as skin itching, redness, and rashes. Nosebleeds, dry nose, muscle and joint pain, headaches, and fatigue are also frequent Accutane side effects. Hair loss or thinning, increased risk of sunburn, and changes in liver function and blood sugar levels can occur. Additionally, mood changes like depression and anxiety may arise. While these side effects are usually mild and temporary, regular monitoring by a dermatologist is crucial to minimize risks and ensure safe treatment, as rare cases can be severe.